Infectivity of Leishmania donovani primary culture promastigotes for golden hamsters. Short communication.
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منابع مشابه
Inhibition of in vitro macrophage digestion capacity by infection with Leishmania donovani (Protozoa: Kinetoplastida).
Promastigotes of Leishmania donovani transformed into amastigotes and survived in cultured macrophages. Promastigotes of Leptomonas costoris, a kinetoplastid parasite of water striders, transformed into amastigotes but did not survive in cultured macrophages. A significant difference in size between the two species of parasitic protozoa allowed development of a bioassay in which the in vitro di...
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Leishmania produce several types of mucin-like glycoproteins called proteophosphoglycans (PPGs) which exist as secretory as well as surface-bound forms in both promastigotes and amastigotes. The structure and function of PPGs have been reported to be species and stage specific as in the case of Leishmania major and Leishmania mexicana; there has been no such information available for Leishmania...
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Maintenance and regulation of the asymmetric lipid distribution across eukaryotic plasma membranes is governed by the concerted action of specific membrane proteins controlling lipid movement across the bilayer. Here, we show that the miltefosine transporter (LdMT), a member of the P4-ATPase subfamily in Leishmania donovani, and the Cdc50-like protein LdRos3 form a stable complex that plays an ...
متن کاملTransgenic Leishmania donovani clinical isolates expressing green fluorescent protein constitutively for rapid and reliable ex vivo drug screening.
OBJECTIVES Several Leishmania strains with episomal expression of green fluorescent protein (GFP) require constant drug pressure for its continuous expression and hence limit its use in ex vivo or in vivo systems. The aim of this study was to alleviate this problem by stably integrating the GFP gene into the parasite genome, so as to use these transfectants for ex vivo and in vivo drug screenin...
متن کاملLeishmania donovani ornithine decarboxylase is indispensable for parasite survival in the mammalian host.
Mutations within the polyamine biosynthetic pathway of Leishmania donovani, the etiological agent of visceral leishmaniasis, confer polyamine auxotrophy to the insect vector or promastigote form of the parasite. However, whether the infectious or amastigote form of the parasite requires an intact polyamine pathway has remained an open question. To address this issue, conditionally lethal Deltao...
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ورودعنوان ژورنال:
- Acta tropica
دوره 38 1 شماره
صفحات -
تاریخ انتشار 1981